Novel immunodominant neoepitope in a KPC mouse model of pancreatic cancer allowing identification of tumor-specific T cells

Novel immunodominant neoepitope in a KPC mouse model of pancreatic cancer allowing identification of tumor-specific T cells

The 4662 KPC model is one of the most widely used mouse models of pancreatic cancer. It represents an excluded immune phenotype and closely recapitulates the pathophysiology of pancreatic cancer in humans. We set out to identify the endogenous neoepitopes present in 4662 cells. By combining whole-ex...

Full description

Saved in:
Bibliographic Details
Main Authors: Maria Antsiferova, Marco Berrera, Anne-Claire Zagdoun, Maha Raauf, Thuy Trinh Nguyen, Claudio Murgia, Birte Appelt, Christine Trumpfheller, Stephan Gasser, Sylvain Pilet, Valeria Nicolini, Ines Grazina de Matos
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:OncoImmunology
Subjects:
Cancer neoantigen
KPC model
neoepitope
pancreatic cancer
tumor-specific T cells
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2025.2489815
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2025.2489815

Similar Items