Structure optimization at position five of 4-thiazolidinone resulted in new potent PIM1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities for combating colorectal cancer

Structure optimization at position five of 4-thiazolidinone resulted in new potent PIM1 kinase inhibitors with apoptosis induction and caspase 3/7 activation capabilities for combating colorectal cancer

New thymol – 5-phenylthiazolidin-4-one hybrids were synthesized aiming to interact with the lipophilic flexible p-loop of PIM kinase active site via induced-fit binding mode to increase affinity hence anticancer activity against colorectal cancer (CRC). All target compounds were screened for their c...

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Bibliographic Details
Main Authors: Ahmed K. Al-Kubeisi, Saad R. El-Zemity, Marwa M. Abu-Serie, Aly A. Hazzaa, Mostafa M.M. El-Miligy
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Thymol
Thiazolidin-4-one
CRC
PIM kinase
Induced fit docking
MD simulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000354
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