Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values

Characterization of medical device constituents and development of duration-based non-cancer threshold of toxicological concern values

IntroductionIn the absence of sufficient constituent-specific dose-response toxicity data, threshold of toxicological concern (TTC) values are commonly used in toxicological risk assessment of medical device (MD) constituents. When experimental data or predictions suggest that a constituent is not l...

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Bibliographic Details
Main Authors: Taylor Builee, Todd A. Kennedy, Valériane Levelut, Megan A. Hahn, Stephen Bond, Michael K. Peterson, Frances K. Hsia, Alessia Stornetta, Kristin J. Erickson, Kimberly D. Ehman, Bindu Prabhakar, Bradford D. Bagley, Sherry P. Parker
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Toxicology
Subjects:
threshold of toxicological concern
medical device
less than lifetime
fit for purpose
non-cancer
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1600127/full
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https://www.frontiersin.org/articles/10.3389/ftox.2025.1600127/full

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