Hydroxychloroquine improves manifestation of PE rats under oxidative stress by regulating the PI3K/AKT/mTOR signaling pathway to inhibit autophagy

Hydroxychloroquine improves manifestation of PE rats under oxidative stress by regulating the PI3K/AKT/mTOR signaling pathway to inhibit autophagy

Abstract Preeclampsia is currently thought to be characterized by placental oxidative stress damage. Hydroxychloroquine is known to have antioxidant effects, but there are fewer studies on hydroxychloroquine in oxidative stress in preeclampsia. The main objective of this study was to investigate the...

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Bibliographic Details
Main Authors: Wu Han, Xu Jing, Chu XiaoYan, Huang Wen Wen, Fan Xia, Ren Qin Qin, Wang Ying, Li Xia, Wang Man, Wang Xiu
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Hydroxychloroquine
Oxidative stress
Preeclampsia
Autophagy
PI3K/AKT/mTOR
Online Access:https://doi.org/10.1038/s41598-025-09589-5
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https://doi.org/10.1038/s41598-025-09589-5

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