N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation
Introduction: In hospitalized patients, atrial fibrillation is the most common arrhythmia, and leading cause of cardio-embolic stroke. Objective: To evaluate the association between N-terminal b-type natriuretic peptide pro (NT-proBNP) and left atrial appendage thrombus in persistent atrial fibril...
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| Format: | Article |
| Language: | Spanish |
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ECIMED
2023-11-01
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| Series: | Revista Cubana de Medicina Militar |
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| Online Access: | https://revmedmilitar.sld.cu/index.php/mil/article/view/3065 |
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| _version_ | 1841546418204966912 |
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| author | Chien Do Van Huyen Trang Dang Son Pham Nguyen Minh Quang Luu |
| author_facet | Chien Do Van Huyen Trang Dang Son Pham Nguyen Minh Quang Luu |
| author_sort | Chien Do Van |
| collection | DOAJ |
| description | Introduction: In hospitalized patients, atrial fibrillation is the most common arrhythmia, and leading cause of cardio-embolic stroke.
Objective: To evaluate the association between N-terminal b-type natriuretic peptide pro (NT-proBNP) and left atrial appendage thrombus in persistent atrial fibrillation patients.
Methods: A cross-sectional study, enrolled 139 patients with persistent non-valvular atrial fibrillation. Transthoracic and trans-esophageal echocardiographs were performed in all patients.
Results: Mean age was 70.5 ± 10.6 years, 80.6% male. In patients with LAAT, NT-proBNP was positively correlated with left ventricular end diastolic diameter (LVEDD) (r=0.345), left ventricular end-systolic diameter (LVEDS) (r= 0.449), E/e' (r=0.445), and left atrial spontaneous echo contrast (LA SEC) (r=0.478), and negatively correlated with left ventricular ejection fraction (LVEF) (r=-0.473), left atrial strain (r= -0.301), strain rate (r= -0.283), and e'(r= -0.458). In patients without LAAT, NT-proBNP was positively correlated with LVEDD (r= 0.333), LVESD (r= 0.358), E (r= 0.318), E/e' (r= 0.411), left atrial volume index (LAVI) (r= 0.421), and negatively correlated with LVEF (r= -0.307). Plasma NT-proBNP (> 1279 pg/mL) could be used to predict LAAT (AUC= 0.639; Se= 67.7%, Sp= 60.2%). In patients with ejection fraction > 50%, the cutoff value of NT-proBNP to predict LAAT was 1325 pg/mL (AUC= 0.572; Se= 57.9%, Sp= 78.3%). Multiple logistic regression analysis showed that prior stroke, E/e' index, and NT-proBNP correlated with LAAT (r= 0.887; p< 0.001; r= -0.092, p= 0.035 and 0.022; p= 0.004, respectively).
Conclusion: Plasma NT-proBNP levels and E/e' index are associated with LAAT in patients with persistent atrial fibrillation.
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| format | Article |
| id | doaj-art-30400d1d3ed84d488897d86c969de482 |
| institution | Kabale University |
| issn | 1561-3046 |
| language | Spanish |
| publishDate | 2023-11-01 |
| publisher | ECIMED |
| record_format | Article |
| series | Revista Cubana de Medicina Militar |
| spelling | doaj-art-30400d1d3ed84d488897d86c969de4822025-01-10T19:02:25ZspaECIMEDRevista Cubana de Medicina Militar1561-30462023-11-01524871N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillationChien Do Van0https://orcid.org/0000-0002-0965-3855Huyen Trang Dang1https://orcid.org/0009-0001-0514-8931Son Pham Nguyen2https://orcid.org/0000-0002-0443-9083Minh Quang Luu3https://orcid.org/0000-0003-4478-6220Central Military Hospital. Department of Cardiology. Hanoi, VietnamMilitary Hospital. Hue, VietnamCentral Military Hospital. Department of Cardiology. Hanoi, VietnamCentral Military Hospital. Department of Cardiology. Hanoi, VietnamIntroduction: In hospitalized patients, atrial fibrillation is the most common arrhythmia, and leading cause of cardio-embolic stroke. Objective: To evaluate the association between N-terminal b-type natriuretic peptide pro (NT-proBNP) and left atrial appendage thrombus in persistent atrial fibrillation patients. Methods: A cross-sectional study, enrolled 139 patients with persistent non-valvular atrial fibrillation. Transthoracic and trans-esophageal echocardiographs were performed in all patients. Results: Mean age was 70.5 ± 10.6 years, 80.6% male. In patients with LAAT, NT-proBNP was positively correlated with left ventricular end diastolic diameter (LVEDD) (r=0.345), left ventricular end-systolic diameter (LVEDS) (r= 0.449), E/e' (r=0.445), and left atrial spontaneous echo contrast (LA SEC) (r=0.478), and negatively correlated with left ventricular ejection fraction (LVEF) (r=-0.473), left atrial strain (r= -0.301), strain rate (r= -0.283), and e'(r= -0.458). In patients without LAAT, NT-proBNP was positively correlated with LVEDD (r= 0.333), LVESD (r= 0.358), E (r= 0.318), E/e' (r= 0.411), left atrial volume index (LAVI) (r= 0.421), and negatively correlated with LVEF (r= -0.307). Plasma NT-proBNP (> 1279 pg/mL) could be used to predict LAAT (AUC= 0.639; Se= 67.7%, Sp= 60.2%). In patients with ejection fraction > 50%, the cutoff value of NT-proBNP to predict LAAT was 1325 pg/mL (AUC= 0.572; Se= 57.9%, Sp= 78.3%). Multiple logistic regression analysis showed that prior stroke, E/e' index, and NT-proBNP correlated with LAAT (r= 0.887; p< 0.001; r= -0.092, p= 0.035 and 0.022; p= 0.004, respectively). Conclusion: Plasma NT-proBNP levels and E/e' index are associated with LAAT in patients with persistent atrial fibrillation. https://revmedmilitar.sld.cu/index.php/mil/article/view/3065NT-proBNPleft atrial appendagethrombosisatrial fibrillation. |
| spellingShingle | Chien Do Van Huyen Trang Dang Son Pham Nguyen Minh Quang Luu N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation Revista Cubana de Medicina Militar NT-proBNP left atrial appendage thrombosis atrial fibrillation. |
| title | N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| title_full | N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| title_fullStr | N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| title_full_unstemmed | N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| title_short | N-terminal pro-B-type Natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| title_sort | n terminal pro b type natriuretic peptide levels and left atrial appendage thrombosis in patients with persistent atrial fibrillation |
| topic | NT-proBNP left atrial appendage thrombosis atrial fibrillation. |
| url | https://revmedmilitar.sld.cu/index.php/mil/article/view/3065 |
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