Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model

Ultrasound guided blood brain barrier opening using a diagnostic probe in a whole brain model

Abstract The blood–brain barrier (BBB) poses a significant challenge to drug delivery to the brain. A promising approach involves low-frequency, low-intensity pulsed ultrasound (US) waves combined with intravenously injected microbubbles (MB) to temporarily and non-invasively open the BBB. However,...

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Main Authors: Matteo Gionso, Erica Herlin, Laura Uva, Francesco Guidi, Piero Tortoli, Giovanni Durando, Luca Raspagliesi, Nicoletta Corradino, Veronica Percuoco, Francesco DiMeco, Marco De Curtis, Laura Librizzi, Francesco Prada
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-94660-4
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https://doi.org/10.1038/s41598-025-94660-4

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