Bioinformatics insights into the role of GFPT1 in breast invasive carcinoma: implications for tumor prognosis, immune modulation, and therapeutic applications

Bioinformatics insights into the role of GFPT1 in breast invasive carcinoma: implications for tumor prognosis, immune modulation, and therapeutic applications

BackgroundMetabolic reprogramming is a hallmark of cancer, including alterations in the hexosamine biosynthesis pathway (HBP). Glutamine-fructose-6-phosphate transaminase 1 (GFPT1) is the key regulatory enzyme in the HBP; however, its role in invasive breast carcinoma remains underexplored.MethodsTh...

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Bibliographic Details
Main Authors: Jianghui Liang, Xiaolian Deng, Yingyi Zhang, Tianchi Fei, Muzi Ouyang, Chengjie Yu, Yang Xiang, Dongwei Jia, Fangfang Duan
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Genetics
Subjects:
GFPT1
breast invasive carcinoma (BRCA)
prognosis
immune infiltration
chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1482929/full
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https://www.frontiersin.org/articles/10.3389/fgene.2024.1482929/full

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