Transition of CELF2 PAS usage promotes recovery of refractory JDM through alternative splicing regulation of CTSB

Transition of CELF2 PAS usage promotes recovery of refractory JDM through alternative splicing regulation of CTSB

Alternative splicing (AS) and alternative polyadenylation (APA) are widespread in the immune system. However, their precise role in juvenile dermatomyositis (JDM) remains unclear. Based on the polyadenylation sequencing platform, we described APA landscape of refractory JDM before and after autologo...

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Bibliographic Details
Main Authors: Jinyan Wei, Dan Zhang, Xiaolin Lu, Kexiang Zhang, Rong Liu, Xin Wu, Jia Zhu, Jianming Lai, Gaixiu Su, Li Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: RNA/DNA Editing
juvenile dermatomyositis
JDM
alternative polyadenylation
APA
alternative splicing
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001787
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http://www.sciencedirect.com/science/article/pii/S2162253125001787

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