Petiveria alliacea and Caesalpinia spinosa extracts reduce the generation of cancer-associated fibroblasts in a 3D platform representative of the tumor microenvironment

Petiveria alliacea and Caesalpinia spinosa extracts reduce the generation of cancer-associated fibroblasts in a 3D platform representative of the tumor microenvironment

Abstract Background The tumor microenvironment (TME) is a complex network of cellular and acellular participants, each of which contributes to ensuring tumor growth. Cancer-associated fibroblasts (CAFs) represent a key TME population that actively participates in stromal remodeling and metabolic cou...

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Bibliographic Details
Main Authors: María Camila Jimenez, Paola Lasso, Susana Fiorentino, Alfonso Barreto
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cancer Cell International
Subjects:
Tumor microenvironment
3D culture systems
Plant-based therapies
Cancer-associated fibroblasts
Natural therapies
Drug screening
Online Access:https://doi.org/10.1186/s12935-025-03860-5
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https://doi.org/10.1186/s12935-025-03860-5

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