Pyrazolopyridine pyrimidone hybrids as potential DprE1 inhibitors, design, synthesis and biological evaluation as antitubercular agents

Pyrazolopyridine pyrimidone hybrids as potential DprE1 inhibitors, design, synthesis and biological evaluation as antitubercular agents

Abstract Tuberculosis (TB) remains a major global health challenge. This study presents the design, synthesis, and evaluation of some novel pyrazolo[3,4-b]pyridine-pyrimidone derivatives targeting Mycobacterium tuberculosis (Mtb). The compounds were assessed for anti-tubercular activity using the Mi...

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Bibliographic Details
Main Authors: Moksh Shah, Iva Patel, Pratik Khona, Harnisha Patel, Mange Ram Yadav, Afzal Nagani
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Pyrazolopyridine-Pyrimidone
Anti-tubercular
Molecular docking
DFT
Molecular dynamics
Online Access:https://doi.org/10.1038/s41598-025-14734-1
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https://doi.org/10.1038/s41598-025-14734-1

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