Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

Abstract Dysregulated cell death leading to uncontrolled cell proliferation is a hallmark of cancer. Chemotherapy-induced cell death is critical for the success of cancer treatment but this process is impaired by metabolic byproducts. How these byproducts interfere with anti-cancer therapy is unclea...

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Main Authors: Hyun Bae, Seonghyun Moon, Mengmeng Chang, Fenfen Zhang, Yeonseo Jang, Wonyoung Kim, Soyeon Kim, Minjie Fu, Jaemin Lim, Seongjun Park, Chirag N. Patel, Raghvendra Mall, Min Zheng, Si Ming Man, Rajendra Karki
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60226-1
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https://doi.org/10.1038/s41467-025-60226-1

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