Synthesis and Evaluation of <sup>68</sup>Ga- and <sup>177</sup>Lu-Labeled [diF-Pro<sup>14</sup>]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer

Synthesis and Evaluation of <sup>68</sup>Ga- and <sup>177</sup>Lu-Labeled [diF-Pro<sup>14</sup>]Bombesin(6−14) Analogs for Detection and Radioligand Therapy of Gastrin-Releasing Peptide Receptor-Expressing Cancer

<b>Background/Objectives:</b> Overexpressed in various solid tumors, the gastrin-releasing peptide receptor (GRPR) is a promising target for cancer diagnosis and therapy. However, the high pancreas uptake of the current clinically evaluated GRPR-targeted radiopharmaceuticals limits their...

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Bibliographic Details
Main Authors: Lei Wang, Chao-Cheng Chen, Devon Chapple, Antonio A. W. L. Wong, Sara Kurkowska, Wing Sum Lau, Carlos F. Uribe, François Bénard, Kuo-Shyan Lin
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Pharmaceuticals
Subjects:
gastrin-releasing peptide receptor
4,4-difluoroproline
gallium-68
lutetium-177
pancreas uptake
Online Access:https://www.mdpi.com/1424-8247/18/2/234
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