Evaluation of safety, immunogenicity, and efficacy of inactivated reverse-genetics-based H5N8 highly pathogenic avian influenza virus vaccine with various adjuvants via parenteral and mucosal routes in chickens

Evaluation of safety, immunogenicity, and efficacy of inactivated reverse-genetics-based H5N8 highly pathogenic avian influenza virus vaccine with various adjuvants via parenteral and mucosal routes in chickens

BackgroundHighly pathogenic H5Nx avian influenza (HPAI) poses a significant threat to poultry health globally, necessitating the development of effective vaccination strategies.MethodsThis study assessed the immunogenicity and efficacy of a reverse-genetics-derived, Differentiating Infected from Vac...

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Main Authors: Kairat Tabynov, Aidana Kuanyshbek, Leila Yelchibayeva, Kuantay Zharmambet, Zauresh Zhumadilova, Gleb Fomin, Nikolai Petrovsky, Olaitan C. Shekoni, Gourapura J. Renukaradhya, Kaissar Tabynov
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Immunology
Subjects:
avian influenza
vaccine
H5N8
reverse genetics; efficacy
adjuvants
nanoparticles
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539492/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1539492/full

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