Mitochondrial Uncoupler, 2,4-Dinitrophenol, Reduces Spinal Cord Paralysis and Retinal Ganglion Cell Loss in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Mitochondrial Uncoupler, 2,4-Dinitrophenol, Reduces Spinal Cord Paralysis and Retinal Ganglion Cell Loss in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Optic neuritis is an inflammatory demyelinating disease of the optic nerve that often occurs in multiple sclerosis (MS) patients. Sixty percent of patients develop some level of permanent visual loss due to retinal ganglion cell (RGC) damage following optic neuritis, with no known treatment to preve...

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Bibliographic Details
Main Authors: Nuala O’Neill, Reas S. Khan, Suad Abd Alhadi, Kimberly E. Dine, John G. Geisler, Brahim Chaqour, Ahmara G. Ross, Kenneth S. Shindler
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
EAE
optic neuritis
RGC neuroprotection
dinitrophenol
mitochondrial uncoupling agent
Online Access:https://www.mdpi.com/2218-273X/15/2/189
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