Exploring β-lactam interactions with DacB1: unraveling optimal therapies for combating drug-resistant Mycobacterium tuberculosis

Exploring β-lactam interactions with DacB1: unraveling optimal therapies for combating drug-resistant Mycobacterium tuberculosis

ABSTRACT Tuberculosis (TB) continues to pose a global public health threat, exacerbated by rising drug-resistant strains of Mycobacterium tuberculosis (Mtb). DacB1, a D,D-carboxypeptidase critical in Mtb peptidoglycan biosynthesis, is a promising target for β-lactam antibiotics (BLs), which remain u...

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Main Authors: Mary Nantongo, David C. Nguyen, Eunjeong Shin, Christopher R. Bethel, Magdalena A. Taracila, Khalid M. Dousa, Qing Li, Shane Fletcher, Sebastian G. Kurz, Barry N. Kreiswirth, W. Henry Boom, Steve Holland, Eric J. Rubin, Robert A. Bonomo
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
Drug-resistant TB
β-lactam antibiotics
Mycobacterium tuberculosis
peptidoglycan
D, D-carboxypeptidases
β-lactamase inhibitors
Online Access:https://journals.asm.org/doi/10.1128/mbio.01372-25
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https://journals.asm.org/doi/10.1128/mbio.01372-25

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