Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule

Stereoselective syntheses of (+)-(1R,4R)-5-chloro-, -5-bromo-, -6-chloro-, and -6-bromobicyclo[2.2.1]hept-5-en-2-ones ((+)-2-(+)-5) are presented. The chiroptical properties (CD spectra) of these halogenated derivatives are compared with those of the non-substituted (+)-(1R,4R)-bicyclo[2.2.1]hept-5...

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Main Authors: Antonella Lettieri, Pierre-Alain Carrupt, Pierre Vogel
Format: Article
Language:deu
Published: Swiss Chemical Society 1988-01-01
Series:CHIMIA
Online Access:https://www.chimia.ch/chimia/article/view/9825
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author Antonella Lettieri
Pierre-Alain Carrupt
Pierre Vogel
author_facet Antonella Lettieri
Pierre-Alain Carrupt
Pierre Vogel
author_sort Antonella Lettieri
collection DOAJ
description Stereoselective syntheses of (+)-(1R,4R)-5-chloro-, -5-bromo-, -6-chloro-, and -6-bromobicyclo[2.2.1]hept-5-en-2-ones ((+)-2-(+)-5) are presented. The chiroptical properties (CD spectra) of these halogenated derivatives are compared with those of the non-substituted (+)-(1R,4R)-bicyclo[2.2.1]hept-5-en-2-one ((+)-1) and analyzed in the light of the General Octant Rule and the Dekkers’ Quantitative Chirality Rule for the highest wavelength Cotton Effects of β,γ-enones.
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publisher Swiss Chemical Society
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series CHIMIA
spelling doaj-art-2f5f4da73a004b77a4cd1f75521021f22025-08-20T02:29:51ZdeuSwiss Chemical SocietyCHIMIA0009-42932673-24241988-01-0142110.2533/chimia.1988.27Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality RuleAntonella Lettieri0Pierre-Alain Carrupt1Pierre Vogel2Institut de Chimie Organique Université de Lausanne Rue de la Barre 2 CH-1005 LausanneInstitut de Chimie Organique Université de Lausanne Rue de la Barre 2 CH-1005 LausanneInstitut de Chimie Organique Université de Lausanne Rue de la Barre 2 CH-1005 Lausanne Stereoselective syntheses of (+)-(1R,4R)-5-chloro-, -5-bromo-, -6-chloro-, and -6-bromobicyclo[2.2.1]hept-5-en-2-ones ((+)-2-(+)-5) are presented. The chiroptical properties (CD spectra) of these halogenated derivatives are compared with those of the non-substituted (+)-(1R,4R)-bicyclo[2.2.1]hept-5-en-2-one ((+)-1) and analyzed in the light of the General Octant Rule and the Dekkers’ Quantitative Chirality Rule for the highest wavelength Cotton Effects of β,γ-enones. https://www.chimia.ch/chimia/article/view/9825
spellingShingle Antonella Lettieri
Pierre-Alain Carrupt
Pierre Vogel
Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
CHIMIA
title Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
title_full Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
title_fullStr Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
title_full_unstemmed Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
title_short Synthesis and Circular Dichroism of 5- and 6-Halogenobicyclo[2.2.1]hept-5-en-2-ones; Tests for the Dekkers' Quantitative Chirality Rule
title_sort synthesis and circular dichroism of 5 and 6 halogenobicyclo 2 2 1 hept 5 en 2 ones tests for the dekkers quantitative chirality rule
url https://www.chimia.ch/chimia/article/view/9825
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AT pierrealaincarrupt synthesisandcirculardichroismof5and6halogenobicyclo221hept5en2onestestsforthedekkersquantitativechiralityrule
AT pierrevogel synthesisandcirculardichroismof5and6halogenobicyclo221hept5en2onestestsforthedekkersquantitativechiralityrule