Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study

Incidence, clinical and genomic trends of hospital- and Non-hospital-onset KPC-producing Klebsiella pneumoniae infections before and during the COVID-19 era: a ten-year interrupted time series study

Abstract Background Infections caused by KPC-producing Klebsiella pneumoniae (KPC-KP) represent a persistent public health challenge. This prospective study examines ten-year trends, clinical features, and genomic epidemiology of hospital-onset (HOI) and non-hospital-onset (non-HOI, including health...

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Main Authors: Manuel Recio-Rufián, Teresa López-Viñau, Víctor Gálvez-Soto, Ángela Cano, Rafael Ruiz-Montero, Belén Gutiérrez-Gutiérrez, Irene Gracia-Ahufinger, Germán Peñalva, Juan Antonio Marín-Sanz, Miriam Marín-Sanz, David Segorbe, Juan Jesús Pineda-Capitán, Montserrat Muñoz-Rosa, Cristina Riazzo, Federico Giovagnorio, Elisa Ruiz-Arabi, José David Torres-Peña, Juan José Castón, Isabel Machuca, Inmaculada Salcedo-Leal, Luis Martínez-Martínez, Elena Pérez-Nadales, Julián Torre-Cisneros, KLEBMAN study group
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Antimicrobial Resistance and Infection Control
Subjects:
KPC-producing Klebsiella pneumoniae
Hospital-onset infections
Healthcare-associated infections
Community-acquired infections
Antimicrobial stewardship program (ASP)
COVID-19 infection prevention and control (IPC)
Online Access:https://doi.org/10.1186/s13756-025-01614-6
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https://doi.org/10.1186/s13756-025-01614-6

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