Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

Uncovering the genetic architecture and evolutionary roots of androgenetic alopecia in African men

Summary: Androgenetic alopecia is a highly heritable trait. However, much of our understanding about the genetics of male-pattern baldness comes from individuals of European descent. Here, we examined a dataset comprising 2,136 men from Ghana, Nigeria, Senegal, and South Africa that were genotyped u...

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Main Authors: Rohini Janivara, Ujani Hazra, Aaron Pfennig, Maxine Harlemon, Michelle S. Kim, Muthukrishnan Eaaswarkhanth, Wenlong C. Chen, Adebola Ogunbiyi, Paidamoyo Kachambwa, Lindsay N. Petersen, Mohamed Jalloh, James E. Mensah, Andrew A. Adjei, Ben Adusei, Maureen Joffe, Serigne M. Gueye, Oseremen I. Aisuodionoe-Shadrach, Pedro W. Fernandez, Thomas E. Rohan, Caroline Andrews, Timothy R. Rebbeck, Akindele O. Adebiyi, Ilir Agalliu, Joseph Lachance
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:HGG Advances
Subjects:
Africa
evolutionary genetics
generalizability
GWAS
male-pattern baldness
polygenic scores
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247725000314
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