New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis
Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alte...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2017/1813086 |
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| author | Zezheng Gao Qingwei Li Xuemin Wu Xuemin Zhao Linhua Zhao Xiaolin Tong |
| author_facet | Zezheng Gao Qingwei Li Xuemin Wu Xuemin Zhao Linhua Zhao Xiaolin Tong |
| author_sort | Zezheng Gao |
| collection | DOAJ |
| description | Diabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking. Here, we have proposed that many herbal monomers and formulae improve glucose homeostasis and diabetes through the BMID axis; B represents gut microbiota, M means mucosal immunity, I represents inflammation, and D represents diabetes. Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside, M. charantia extract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. This review was intended to provide new perspectives and strategies for future diabetes research and product. |
| format | Article |
| id | doaj-art-2f57fa69b88f406e86c569693fecde9b |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2f57fa69b88f406e86c569693fecde9b2025-02-03T05:59:45ZengWileyJournal of Immunology Research2314-88612314-71562017-01-01201710.1155/2017/18130861813086New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” AxisZezheng Gao0Qingwei Li1Xuemin Wu2Xuemin Zhao3Linhua Zhao4Xiaolin Tong5Department of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100054, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100054, ChinaShenzhen Hospital, Guangzhou University of Chinese Medicine, Guangzhou 518034, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100054, ChinaLaboratory of Molecular Biology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, ChinaDepartment of Endocrinology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100054, ChinaDiabetes, especially type 2, has been rapidly increasing all over the world. Although many drugs have been developed and used to treat diabetes, side effects and long-term efficacy are of great challenge. Therefore, natural health product and dietary supplements have been of increasing interest alternatively. In this regard, Chinese herbs and herbal products have been considered a rich resource of product development. Although increasing evidence has been produced from various scientific studies, the mechanisms of action are lacking. Here, we have proposed that many herbal monomers and formulae improve glucose homeostasis and diabetes through the BMID axis; B represents gut microbiota, M means mucosal immunity, I represents inflammation, and D represents diabetes. Chinese herbs have been traditionally used to treat diabetes, with minimal side and toxic effects. Here, we reviewed monomers such as berberine, ginsenoside, M. charantia extract, and curcumin and herbal formulae such as Gegen Qinlian Decoction, Danggui Liuhuang Decoction, and Huanglian Wendan Decoction. This review was intended to provide new perspectives and strategies for future diabetes research and product.http://dx.doi.org/10.1155/2017/1813086 |
| spellingShingle | Zezheng Gao Qingwei Li Xuemin Wu Xuemin Zhao Linhua Zhao Xiaolin Tong New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis Journal of Immunology Research |
| title | New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis |
| title_full | New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis |
| title_fullStr | New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis |
| title_full_unstemmed | New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis |
| title_short | New Insights into the Mechanisms of Chinese Herbal Products on Diabetes: A Focus on the “Bacteria-Mucosal Immunity-Inflammation-Diabetes” Axis |
| title_sort | new insights into the mechanisms of chinese herbal products on diabetes a focus on the bacteria mucosal immunity inflammation diabetes axis |
| url | http://dx.doi.org/10.1155/2017/1813086 |
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