Identification and Characterization of Fully Human FOLR1-Targeting CAR T Cells for the Treatment of Ovarian Cancer

Identification and Characterization of Fully Human FOLR1-Targeting CAR T Cells for the Treatment of Ovarian Cancer

CAR T cell therapy has been an effective treatment option for hematological malignancies. However, the therapeutic potential of CAR T cells can be reduced by several constraints, partly due to immunogenicity and toxicities. The lack of established workflows enabling thorough evaluation of new candid...

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Bibliographic Details
Main Authors: Maria Bethke, Pierre Abramowski, Miriam Droste, André Felsberger, Lisa Kochsiek, Bettina Kotter, Luisa Plettig, Kateryna Antonova, Salpy Baghdo, Nico Burzan, Florian Tomszak, Manuel Martinez-Osuna, Dominik Eckardt, Christoph Herbel
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
CAR T cells
FOLR1
tissue cross-reactivity
immunotherapy
spatial multiplex
lead selection
Online Access:https://www.mdpi.com/2073-4409/13/22/1880
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