Innate immune training in the neonatal response to sepsis

Innate immune training in the neonatal response to sepsis

Abstract Neonates, especially those born prematurely, are highly vulnerable to infection-induced mortality. Numerous observational and immunological studies in newborns have shown that live attenuated vaccines have beneficial, non-specific effects (NSEs) against secondary infections to unrelated pat...

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Main Authors: Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain, Ricardo F. Ungaro, Dina C. Nacionales, Leilani Zeumer-Spataro, Feifei Xiao, Philip A. Efron, Lyle L. Moldawer, Guoshuai Cai, Shawn D. Larson
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Neonatal sepsis
Myeloid-derived suppressor cells
BCG
Trained immunity
Single-cell RNA sequencing
Online Access:https://doi.org/10.1186/s10020-025-01179-5
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https://doi.org/10.1186/s10020-025-01179-5

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