T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma

T cells in the microenvironment of solid pediatric tumors: the case of neuroblastoma

Neuroblastoma (NB) is an immunologically “cold” tumor with poor or no inflamed substrates as most of solid pediatric tumors (SPT). Consistent data indicate that NB tumor microenvironment (TME) is dominated by myeloid cells, with little (but variable) T cell infiltration. The obstacles to lymphocyte...

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Bibliographic Details
Main Authors: Enrico Maggi, Nadine Landolina, Enrico Munari, Francesca Romana Mariotti, Nicola Tumino, Paola Vacca, Bruno Azzarone, Lorenzo Moretta
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
immunosuppression
immunotherapy of tumors
solid pediatric tumors
T effector cells
T regulatory cells
tumor infiltrating lymphocytes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544137/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1544137/full

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