New horizon of the combined BCG vaccine with probiotic and liraglutide in augmenting beta cell survival via suppression of TXNIP/NLRP3 pyroptosis signaling in Streptozocin–Induced diabetes mellitestype-1 in rats

New horizon of the combined BCG vaccine with probiotic and liraglutide in augmenting beta cell survival via suppression of TXNIP/NLRP3 pyroptosis signaling in Streptozocin–Induced diabetes mellitestype-1 in rats

Background: An ideal anti-diabetic type-1 pharmacotherapy should combine abrogation of beta cell pyroptosis with enhancement of beta cell mass. Objectives: The study investigated the potential synergism from combining the Bacillus Calmette-Guerin (BCG) vaccine with liraglutide (LIR) and probiotics i...

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Main Authors: Amira Karam Khalifa, Dina Sayed Abdelrahim, Dina Mohamed Mekawy, Reham Mohammad Raafat Hamed, Wafaa Rabee Mohamed, Nagwa Mahmoud Ramadan, Wael Mostafa, Rawan Ellackany, Emad Ali Albadawi, Walla'a A. Osman
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Heliyon
Subjects:
Diabetes
TXNIP
NLRP3
Pyroptosis
Liraglutide
Probiotic
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024149638
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