Effective CAR T-cell targeting of an MUC1 cleavage product

Effective CAR T-cell targeting of an MUC1 cleavage product

Background We developed Chimeric antigen receptor (CAR) T cells targeting mucin 1 (MUC1)* (muk * (muk 1 star)), which is the tumor-associated growth factor receptor form of MUC1. Our antibody, MNC2, uniquely binds to MUC1* on cancer cells but does not bind to full-length MUC1, which is expressed on...

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Main Authors: David D Smith, Benoit J Smagghe, Mark G Carter, Kevin R Yi, Jac-Leen S S Nash, Trevor J Grant, Dan S Miller, Scott T Moe, Michael J Nash, Natalie K Miller, Laura L Agarkov, Jacy P Marquez, Andrew K Stewart, Cynthia C Bamdad
Format: Article
Language:English
Published: BMJ Publishing Group 2025-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/5/e010577.full
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https://jitc.bmj.com/content/13/5/e010577.full

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