Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases
Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of preg...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2015/952571 |
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| author | Shernan G. Holtan Yiyi Chen Rajani Kaimal Douglas J. Creedon Elizabeth Ann L. Enninga Wendy K. Nevala Svetomir N. Markovic |
| author_facet | Shernan G. Holtan Yiyi Chen Rajani Kaimal Douglas J. Creedon Elizabeth Ann L. Enninga Wendy K. Nevala Svetomir N. Markovic |
| author_sort | Shernan G. Holtan |
| collection | DOAJ |
| description | Several recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed. |
| format | Article |
| id | doaj-art-2f02ca5c41e84dd28542ae238916e02c |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-2f02ca5c41e84dd28542ae238916e02c2025-02-03T05:50:06ZengWileyJournal of Immunology Research2314-88612314-71562015-01-01201510.1155/2015/952571952571Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation IncreasesShernan G. Holtan0Yiyi Chen1Rajani Kaimal2Douglas J. Creedon3Elizabeth Ann L. Enninga4Wendy K. Nevala5Svetomir N. Markovic6Division of Hematology, Oncology, and Transplantation, University of Minnesota, 420 Delaware Street, MMC 480, Minneapolis, MN 55455, USADepartment of Public Health and Preventive Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USADepartment of Public Health and Preventive Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USADepartment of Obstetrics and Gynecology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USADepartment of Immunology, Mayo Clinic Graduate School of Medicine, 200 First Street SW, Rochester, MN 55905, USASeveral recent studies have shown differences in the maternal immune milieu at different phases of pregnancy, but most studies have been cross-sectional or of relatively few time points. Levels of 42 cytokines were determined using a multiplex bead-based assay on archived serum from a cohort of pregnant women N=16 at median of 18 time points tested, from the first trimester through to parturition, per woman. Unconditional growth modeling was then used to determine time-dependent changes in levels of these cytokines. Macrophage-derived chemokine (MDC, aka CCL22) decreases as pregnancy progresses. IL-1β, IL-6, IL-8, IL-12p70, IL-13, IL-15, IP-10, and FLT3-ligand increase as a function of gestational weeks, and IFNα2, IL-1ra, IL-3, IL-9, IL-12p40, and soluble CD40 ligand increase as a function of trimester. As pregnancy normally progresses, a maternal shift away from a type 2-biased immune response and toward an inflammatory/counterregulatory response is observed.http://dx.doi.org/10.1155/2015/952571 |
| spellingShingle | Shernan G. Holtan Yiyi Chen Rajani Kaimal Douglas J. Creedon Elizabeth Ann L. Enninga Wendy K. Nevala Svetomir N. Markovic Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases Journal of Immunology Research |
| title | Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases |
| title_full | Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases |
| title_fullStr | Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases |
| title_full_unstemmed | Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases |
| title_short | Growth Modeling of the Maternal Cytokine Milieu throughout Normal Pregnancy: Macrophage-Derived Chemokine Decreases as Inflammation/Counterregulation Increases |
| title_sort | growth modeling of the maternal cytokine milieu throughout normal pregnancy macrophage derived chemokine decreases as inflammation counterregulation increases |
| url | http://dx.doi.org/10.1155/2015/952571 |
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