Nebivolol Exerts Hepatoprotective Activity During CLP-Induced Sepsis by Modulating Oxidative Stress, Liver Regeneration, and AKT/MAPK Pathways in Rats

Nebivolol Exerts Hepatoprotective Activity During CLP-Induced Sepsis by Modulating Oxidative Stress, Liver Regeneration, and AKT/MAPK Pathways in Rats

Sepsis is a potentially catastrophic organ dysfunction arising from an infection-induced immunologic reaction leading to severe inflammation, progression of septic shock, and damage to body organs. Sepsis is marked by noticeable hepatotoxicity caused by activating oxidative stress, inflammation, and...

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Main Authors: Rahma Tharwat Sabra, Amany Abdlrehim Bekhit, Nourhan Tharwat Sabra, Nadia Ahmed Abd El-Moeze, Moustafa Fathy
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Stresses
Subjects:
Nebivolol
CLP
Hepatotoxicity
Apoptosis
NF-κB
AKT/MAPK crosstalk
Online Access:https://www.mdpi.com/2673-7140/4/4/53
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