Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

Anaplastic lymphoma kinase (ALK; also known as ALK tyrosine kinase receptor) inhibitors (ALKi) are effective in treating lung cancer patients with chromosomal rearrangement of ALK. However, continuous treatment with ALKis invariably leads to acquired resistance in cancer cells. In this study, we pro...

Full description

Saved in:
Bibliographic Details
Main Authors: Sang‐Min Park, Keeok Haam, Haejeong Heo, Doyeong Kim, Min‐Ju Kim, Hyo‐Jung Jung, Seongwon Cha, Mirang Kim, Haeseung Lee
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Molecular Oncology
Subjects:
acquired resistance
ALK inhibitors
connectivity map
emetine
transcriptome‐based drug repositioning
Online Access:https://doi.org/10.1002/1878-0261.13738
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/1878-0261.13738

Similar Items