A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

A Novel Pot-Economy Approach to the Synthesis of Triantennary GalNAc-Oligonucleotide

N-Acetylgalactosamine (GalNAc) is an efficient and multifunctional delivery tool in the development and synthesis of chemically modified oligonucleotide therapeutics (conjugates). Such therapeutics demonstrate improved potency in vivo due to the selective and efficient delivery to hepatocytes in the...

Full description

Saved in:
Bibliographic Details
Main Authors: Artem Evgenievich Gusev, Vladimir Nikolaevich Ivanov, Nikolai Andreevich Dmitriev, Aleksandr Viktorovich Kholstov, Vladislav Aleksandrovich Vasilichin, Ilya Andreevich Kofiadi, Musa Rakhimovich Khaitov
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
oligonucleotides
phosphoramidite
GalNAc
N-acetylgalactosamine
siRNA
L96
Online Access:https://www.mdpi.com/1420-3049/29/24/5959
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.mdpi.com/1420-3049/29/24/5959

Similar Items