Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma

Neural crest-associated gene FOXD1 induces an immunosuppressive microenvironment by regulating myeloid-derived suppressor cells in melanoma

Background Neural crest-associated genes play pivotal roles in tumor initiation, progression, and the intricate dynamics of the tumor microenvironment (TME). Myeloid-derived suppressor cells (MDSC) within the TME are important in dampening T cell activity and contributing to resistance against immun...

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Main Authors: Jochen Sven Utikal, Viktor Umansky, Kilian Wistuba-Hamprecht, Qian Sun, Rebekka Bitsch, Feyza Gül Özbay Kurt, Daniel Novak, Yuxin Zhang, Shibo Liu, Rui Han, Nina Wang, Juliane Poelchen, Mareike Peter, Huizi Wu, Yiman Wang, Sandra Pardo, Lidong Gong
Format: Article
Language:English
Published: BMJ Publishing Group 2025-04-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/4/e010352.full
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https://jitc.bmj.com/content/13/4/e010352.full

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