T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation

T Cell‐Specific Deficiency of Src Homology 2‐Containing Protein Tyrosine Phosphatase 2 Ameliorates Psoriasis and Colitis by Promoting Treg Differentiation

ABSTRACT Psoriasis and ulcerative colitis are both autoimmune diseases with complex pathogenesis characterized by immune disorders. Src homology 2‐containing protein tyrosine phosphatase 2 (SHP2) is a non‐receptor protein tyrosine phosphatase that acts as a key regulator of immune cell‐mediated infl...

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Bibliographic Details
Main Authors: Shuqiong Zhang, Zijun Ouyang, Zhidan Fan, Haiyan Sun, Haiguo Yu, Xingxin Wu, Yang Sun, Fenli Shao
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:MedComm
Subjects:
adoptive transfer colitis
autoimmune disease
psoriasis
Src homology 2‐containing protein tyrosine phosphatase 2
Treg
Online Access:https://doi.org/10.1002/mco2.70310
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https://doi.org/10.1002/mco2.70310

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