NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy

NLRP3 inflammasome inhibits mitophagy during the progression of temporal lobe epilepsy

Abstract Epilepsy is a neurological disorder involving mitochondrial dysfunction and neuroinflammation. This study examines the relationship between NLRP3 inflammasome activation and mitophagy in the temporal lobe epilepsy, which has not been reported before. A pilocarpine-induced epileptic rat mode...

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Bibliographic Details
Main Authors: Mengqian Wu, Cong Yu, Fuli Wen, Yunfei Li, Xu Zhang, Yinzhou Wang, Xiaoqian Chen, Xingyong Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Temporal lobe epilepsy
Mitophagy
Autophagy
NLRP3 inflammasome
Pyroptosis
Online Access:https://doi.org/10.1038/s41598-025-01087-y
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https://doi.org/10.1038/s41598-025-01087-y

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