Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations

Overexpression of metalloproteinase PAPPA accelerates cancer progression and correlates with immune cell infiltration in gastric cancer: insights from bioinformatics and in vitro investigations

Abstract Background Gastric cancer (GC) is one of the most common malignant tumors in the digestive system. However, the development of its targeted therapies has been slow. Therefore, exploring the mechanisms of malignant behavior of GC is key to developing their treatment methods. Pregnancy-associ...

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Bibliographic Details
Main Authors: Shiya Yu, Shiyao Zheng, Jinwei Qiu, Hongming Lin, Xiaojuan Yu, Huiyan Chen, Junhong Wu, Weihang Wu, Jiong Chen, Yongyuan Chen, Jianwei Chen, Hu Zhao, Yu Wang
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Subjects:
PAPPA
Gastric cancer
Oncogene
Immune cell infiltration
Online Access:https://doi.org/10.1186/s12935-025-03650-z
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https://doi.org/10.1186/s12935-025-03650-z

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