Prediction of cancer cell line-specific synergistic drug combinations based on multi-omics data

Prediction of cancer cell line-specific synergistic drug combinations based on multi-omics data

Compared to single-drug therapy, combination therapy involves the use of two or more drugs to reduce drug dosage, decrease drug toxicity, and improve treatment efficacy. We developed an extreme gradient boosting (XGBoost)-based drug-drug cell line prediction model (XDDC) to predict synergistic drug...

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Bibliographic Details
Main Authors: Jiaqi Chen, Huirui Han, Lingxu Li, Zhengxin Chen, Xinying Liu, Tianyi Li, Xuefeng Wang, Qibin Wang, Ruijie Zhang, Dehua Feng, Lei Yu, Xia Li, Limei Wang, Bing Li, Jin Li
Format: Article
Language:English
Published: PeerJ Inc. 2025-02-01
Series:PeerJ
Subjects:
Drug synergy prediction
Multi-omics
Machine learning
Cancer
Drug combination
Online Access:https://peerj.com/articles/19078.pdf
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