Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways

Revealing the pharmacological mechanisms of nao-an dropping pill in preventing and treating ischemic stroke via the PI3K/Akt/eNOS and Nrf2/HO-1 pathways

Abstract Nao-an Dropping Pill (NADP) is a Chinese patent medicine which commonly used in clinic for ischemic stroke (IS). However, the material basis and mechanism of its prevention or treatment of IS are unclear, then we carried out this study. 52 incoming blood components were resolved by UHPLC-MS...

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Main Authors: Chen Wang, Zhe-Ming Xiong, You-Quan Cong, Zi-Yao Li, Yi Xie, Ying-Xiao Wang, Hui-Min Zhou, Yan-Fang Yang, Jing-Jing Liu, He-Zhen Wu
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Nao-an dropping pill
Ischemic stroke
Network pharmacology
OGD/R
MCAO/R
Mechanism
Online Access:https://doi.org/10.1038/s41598-024-61770-4
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https://doi.org/10.1038/s41598-024-61770-4

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