A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context

A pilot study of senolytics to improve cognition and mobility in older adults at risk for Alzheimer’s diseaseResearch in context

Summary: Background: This single-arm study evaluates the feasibility, safety, and preliminary effects of two senolytic agents, Dasatinib and Quercetin (DQ), in older adults at risk of Alzheimer’s disease. Methods: Participants took 100 mg of Dasatinib and 1250 mg of Quercetin for two days every two...

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Main Authors: Courtney L. Millar, Ike Iloputaife, Kathryn Baldyga, Amani M. Norling, Afroditi Boulougoura, Theodoros Vichos, Tamara Tchkonia, Aaron Deisinger, Tamar Pirtskhalava, James L. Kirkland, Thomas G. Travison, Lewis A. Lipsitz
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:EBioMedicine
Subjects:
Senolytics
Ageing
Cognitive impairment
Gait
Flavonoids
Geroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425000568
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http://www.sciencedirect.com/science/article/pii/S2352396425000568

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