The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling

The RING finger E3 ligase RNF25 protects DNA replication forks independently of its canonical roles in ubiquitin signaling

Abstract The DNA damage response (DDR) mechanisms that allow cells to tolerate DNA replication stress are critically important for genome stability and cell viability. Using an unbiased genetic screen, we identify a role for the RING finger E3 ubiquitin ligase RNF25 in promoting DNA replication stre...

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Main Authors: Lilly F. Chiou, Gaith N. Droby, Deepika Jayaprakash, Jay R. Anand, Xingyuan Zhang, Yang Yang, C. Allie Mills, Thomas S. Webb, Natalie K. Barker, Jialiu Xie, Di Wu, Laura E. Herring, Junya Tomida, Jessica L. Bowser, Cyrus Vaziri
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62368-8
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https://doi.org/10.1038/s41467-025-62368-8

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