Intercellular communication between extracellular vesicles from conditioned macrophages and breast cancer cells drives endocrine therapy resistance

Intercellular communication between extracellular vesicles from conditioned macrophages and breast cancer cells drives endocrine therapy resistance

IntroductionBreast cancer is a leading cause of cancer-related mortality among women, with nearly 70% of cases being estrogen receptor-positive (ER+). While endocrine therapies, such as tamoxifen, have significantly improved patient outcomes, resistance—whether intrinsic or acquired—remains a major...

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Bibliographic Details
Main Authors: María C. Rodriguez-Baili, Miguel Palma-Cobo, César G. Prucca, María Yáñez-Mó, German A. Gil
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
breast cancer
estrogen receptor-positive (ER+)
extracellular vesicles (EVs)
endocrine resistance
tumor-associated macrophages (TAMs)
epithelial-mesenchymal transition (EMT)
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1548724/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1548724/full

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