Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS

Analysis of In Vitro Mirtazapine Metabolites in Human Liver Microsomes by LC-HRMS

ObjectiveTo establish and optimize an in vitro incubation system with human liver microsomes and investigate the in vitro metabolites and possible metabolic pathways of mirtazapine.MethodsThree major metabolites of mirtazapine were selected to optimize the incubation conditions of liver microsomes....

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Bibliographic Details
Main Authors: ZHANG Ying, ZHANG Wen-fang, XU Duo-qi, QIN Shi-yang, YANG Shi-yun, QIAO Jing
Format: Article
Language:zho
Published: Editorial Office of Journal of Forensic Medicine 2024-12-01
Series:Fayixue Zazhi
Subjects:
forensic medicine
toxicological analysis
mirtazapine
human liver microsome
metabolite
metabolic pathway
liquid chromatography-high resolution mass spectrometry （lc-hrms）
Online Access:http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.340606
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http://www.fyxzz.cn/CN/10.12116/j.issn.1004-5619.2024.340606

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