ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts

ECM-dependent regulation of septin 7 in focal adhesions promotes mechanosensing and functional response in fibroblasts

Summary: Fibroblasts are adherent cells that maintain tissue homeostasis by sensing and responding to the extracellular matrix (ECM). Focal adhesions (FAs) link these ECM changes to actomyosin dynamics through changes in its composition, influencing cellular response. Septin-7 (Sept-7) has previousl...

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Bibliographic Details
Main Authors: Wesley Sturgess, Swathi Packirisamy, Rodina Geneidy, Pontus Nordenfelt, Vinay Swaminathan
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:iScience
Subjects:
Mechanobiology
Cell biology
Stem cells research
Online Access:http://www.sciencedirect.com/science/article/pii/S258900422402580X
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