A genome-wide base-editing screen uncovers a pivotal role of paxillin δ ubiquitination in influenza virus infection

Summary: Dissecting host factors critical for viral infection and understanding their mechanisms of action is critical for identifying drug targets. Here, we leverage a genome-wide CRISPR base-editing screen to identify functional lysine residues in host factors required for influenza A virus (IAV)...

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Bibliographic Details
Main Authors: Jiamei Guo, Zhuo Zhou, Ruining Li, Zhifang Xing, Lei Zhang, Shiyi Zhao, Wensheng Wei, Jianwei Wang, Tao Deng
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725005194
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