Inhibition of Transglutaminase 2 by a Selective Small Molecule Inhibitor Reduces Fibrosis and Improves Pulmonary Function in a Bleomycin Mouse Model

Inhibition of Transglutaminase 2 by a Selective Small Molecule Inhibitor Reduces Fibrosis and Improves Pulmonary Function in a Bleomycin Mouse Model

This paper investigates the ability of our selective small molecule TG2 inhibitor 1-155 in reducing fibrosis in a bleomycin-induced pulmonary fibrosis mouse model. Formulated as a fine stable suspension, 1-155 was delivered intranasally (IN) at 3 mg/kg via IN delivery once daily. It significantly in...

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Bibliographic Details
Main Authors: Zhuo Wang, Sriniwas Sriram, Cynthia Ugwoke, Zoe Gale, Maral Tabrizi, Martin Griffin
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Cells
Subjects:
Transglutaminase 2 (TG2)
pulmonary fibrosis
idiopathic pulmonary fibrosis (IPF)
small molecule inhibitor
transforming growth factor β1 (TGFβ1)
α smooth muscle actin (αSMA)
Online Access:https://www.mdpi.com/2073-4409/14/7/497
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