Efficacy, safety and exploratory analysis of neoadjuvant tislelizumab (a PD-1 inhibitor) plus nab-paclitaxel followed by epirubicin/cyclophosphamide for triple-negative breast cancer: a phase 2 TREND trial

Abstract The optimal chemotherapy backbone and specific population of triple-negative breast cancer (TNBC) patients that benefit from neoadjuvant immunotherapy are not well established. This prospective, single-arm, phase II TREND trial assessed the efficacy and safety of tislelizumab plus nab-pacli...

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Main Authors: Qiang Zhang, Mozhi Wang, Yumeng Li, Hengjun Zhang, Yusong Wang, Xiuyun Chen, Litong Yao, Mingke Cui, Haoran Dong, Xiang Li, Jian Liu, Bo Zhu, Yingying Xu
Format: Article
Language:English
Published: Nature Publishing Group 2025-05-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-025-02254-3
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