Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment

Super-resolution imaging in whole cells and tissues via DNA-PAINT on a spinning disk confocal with optical photon reassignment

Abstract Single-Molecule Localization Microscopy (SMLM) has traditionally faced challenges to optimize signal-to-noise ratio, penetration depth, field-of-view (FOV), and spatial resolution simultaneously. Here, we show that DNA-PAINT imaging on a Spinning Disk Confocal with Optical Photon Reassignme...

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Bibliographic Details
Main Authors: Cecilia Zaza, Megan D. Joseph, Olivia P. L. Dalby, Rhian F. Walther, Karol Kołątaj, Germán Chiarelli, Franck Pichaud, Guillermo P. Acuna, Sabrina Simoncelli
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60263-w
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https://doi.org/10.1038/s41467-025-60263-w

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