Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis
Aim. We examined endocannabinoids (ECs) in relation to bariatric surgery and the association between plasma ECs and markers of insulin resistance. Methods. A study of 20 participants undergoing bariatric surgery. Fasting and 2-hour plasma glucose, lipids, insulin, and C-peptide were recorded preoper...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2015/680867 |
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| author | Akhila Mallipedhi Sarah L. Prior Gareth Dunseath Richard M. Bracken Jonathan Barry Scott Caplin Nia Eyre James Morgan John N. Baxter Saoirse E. O’Sullivan Sarir Sarmad David A. Barrett Stephen C. Bain Steve D. Luzio Jeffrey W. Stephens |
| author_facet | Akhila Mallipedhi Sarah L. Prior Gareth Dunseath Richard M. Bracken Jonathan Barry Scott Caplin Nia Eyre James Morgan John N. Baxter Saoirse E. O’Sullivan Sarir Sarmad David A. Barrett Stephen C. Bain Steve D. Luzio Jeffrey W. Stephens |
| author_sort | Akhila Mallipedhi |
| collection | DOAJ |
| description | Aim. We examined endocannabinoids (ECs) in relation to bariatric surgery and the association between plasma ECs and markers of insulin resistance. Methods. A study of 20 participants undergoing bariatric surgery. Fasting and 2-hour plasma glucose, lipids, insulin, and C-peptide were recorded preoperatively and 6 months postoperatively with plasma ECs (AEA, 2-AG) and endocannabinoid-related lipids (PEA, OEA). Results. Gender-specific analysis showed differences in AEA, OEA, and PEA preoperatively with reductions in AEA and PEA in females postoperatively. Preoperatively, AEA was correlated with 2-hour glucose (r=0.55, P=0.01), HOMA-IR (r=0.61, P=0.009), and HOMA %S (r=-0.71, P=0.002). OEA was correlated with weight (r=0.49, P=0.03), waist circumference (r=0.52, P=0.02), fasting insulin (r=0.49, P=0.04), and HOMA-IR (r=0.48, P=0.05). PEA was correlated with fasting insulin (r=0.49, P=0.04). 2-AG had a negative correlation with fasting glucose (r=-0.59, P=0.04). Conclusion. Gender differences exist in circulating ECs in obese subjects. Females show changes in AEA and PEA after bariatric surgery. Specific correlations exist between different ECs and markers of obesity and insulin and glucose homeostasis. |
| format | Article |
| id | doaj-art-2e180d1e96d44c659d2221fcb601aab6 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-2e180d1e96d44c659d2221fcb601aab62025-02-03T07:23:50ZengWileyJournal of Diabetes Research2314-67452314-67532015-01-01201510.1155/2015/680867680867Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose HomeostasisAkhila Mallipedhi0Sarah L. Prior1Gareth Dunseath2Richard M. Bracken3Jonathan Barry4Scott Caplin5Nia Eyre6James Morgan7John N. Baxter8Saoirse E. O’Sullivan9Sarir Sarmad10David A. Barrett11Stephen C. Bain12Steve D. Luzio13Jeffrey W. Stephens14Diabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKWelsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABM University Health Board, Swansea SA6 6NL, UKWelsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABM University Health Board, Swansea SA6 6NL, UKWelsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABM University Health Board, Swansea SA6 6NL, UKWelsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABM University Health Board, Swansea SA6 6NL, UKWelsh Institute of Metabolic and Obesity Surgery, Morriston Hospital, ABM University Health Board, Swansea SA6 6NL, UKDivision of Medical Sciences and Graduate Entry Medicine, University of Nottingham, Royal Derby Hospital, Derby DE22 3DT, UKCentre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKCentre for Analytical Bioscience, School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKDiabetes Research Group, Institute of Life Sciences, Swansea University, Swansea SA2 8PP, UKAim. We examined endocannabinoids (ECs) in relation to bariatric surgery and the association between plasma ECs and markers of insulin resistance. Methods. A study of 20 participants undergoing bariatric surgery. Fasting and 2-hour plasma glucose, lipids, insulin, and C-peptide were recorded preoperatively and 6 months postoperatively with plasma ECs (AEA, 2-AG) and endocannabinoid-related lipids (PEA, OEA). Results. Gender-specific analysis showed differences in AEA, OEA, and PEA preoperatively with reductions in AEA and PEA in females postoperatively. Preoperatively, AEA was correlated with 2-hour glucose (r=0.55, P=0.01), HOMA-IR (r=0.61, P=0.009), and HOMA %S (r=-0.71, P=0.002). OEA was correlated with weight (r=0.49, P=0.03), waist circumference (r=0.52, P=0.02), fasting insulin (r=0.49, P=0.04), and HOMA-IR (r=0.48, P=0.05). PEA was correlated with fasting insulin (r=0.49, P=0.04). 2-AG had a negative correlation with fasting glucose (r=-0.59, P=0.04). Conclusion. Gender differences exist in circulating ECs in obese subjects. Females show changes in AEA and PEA after bariatric surgery. Specific correlations exist between different ECs and markers of obesity and insulin and glucose homeostasis.http://dx.doi.org/10.1155/2015/680867 |
| spellingShingle | Akhila Mallipedhi Sarah L. Prior Gareth Dunseath Richard M. Bracken Jonathan Barry Scott Caplin Nia Eyre James Morgan John N. Baxter Saoirse E. O’Sullivan Sarir Sarmad David A. Barrett Stephen C. Bain Steve D. Luzio Jeffrey W. Stephens Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis Journal of Diabetes Research |
| title | Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis |
| title_full | Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis |
| title_fullStr | Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis |
| title_full_unstemmed | Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis |
| title_short | Changes in Plasma Levels of N-Arachidonoyl Ethanolamine and N-Palmitoylethanolamine following Bariatric Surgery in Morbidly Obese Females with Impaired Glucose Homeostasis |
| title_sort | changes in plasma levels of n arachidonoyl ethanolamine and n palmitoylethanolamine following bariatric surgery in morbidly obese females with impaired glucose homeostasis |
| url | http://dx.doi.org/10.1155/2015/680867 |
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