Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons

Formation of seeding-competent α-synuclein aggregates in parkin-deficient iPSC-derived human neurons

Abstract Loss-of-function mutations in PARK2 (parkin) cause early-onset familial Parkinson’s disease (PD) and may also contribute to sporadic PD. While Lewy bodies, enriched in aggregated phosphorylated α-synuclein (α-Syn), are typical in PD, their presence in PARK2-mediated PD remains debated. Usin...

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Main Authors: Sissel Ida Schmidt, Justyna Okarmus, Daniel Aghaie Madsen, Julie Schmidt Hansen, Emil Gregersen, Hjalte Gram, Lucas S. Winkelmann, Anderson Souza Oliveira, Rachel Heon-Roberts, Brent J. Ryan, Kristine Freude, Morten Blaabjerg, Poul Henning Jensen, Morten Meyer
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-01038-4
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https://doi.org/10.1038/s41531-025-01038-4

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