BIGFAM - variance components analysis from relatives without genotype

Abstract Estimating variance components of phenotypes provides a fundamental basis for understanding complex traits. However, most existing methods require genotype data, which is costly to obtain and often unavailable, limiting their scalability. To address this limitation, we developed BIGFAM, a g...

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Bibliographic Details
Main Authors: Jaeeun Jerry Lee, Buhm Han
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60502-0
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