Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF

Administration of chiglitazar reverses chronic stress-induced depressive-like symptoms in mice via activation of hippocampal PPARα and BDNF

BackgroundDeveloping non-monoamine based novel antidepressants is now popular and necessary. Peroxisome proliferator-activated receptor α (PPARα) has been demonstrated to play a role in the pathophysiology of depression, and several PPARα agonists including WY14643, fenofibrate, and gemfibrozil, hav...

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Main Authors: Jiu-Jian Zhou, Jie Zhao, Shang-Yan Gao, Yuan-yuan Gao, Cheng Chen, Yi Ding, Zhong-hua Wu, Pu-Jian Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
brain-derived neurotrophic factor
chiglitazar
chronic stress
depression
hippocampus
peroxisome proliferator-activated receptor α
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1587399/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1587399/full

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