IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia

IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia

Hypercholesterolemia is a significant risk factor for the development of atherosclerosis. 2′,3′,5′-Tri-O-acetyl-N6-(3-hydroxyphenyl) adenosine (IMM-H007), a novel AMPK agonist, has shown protective effects in metabolic diseases. However, its impact on cholesterol and triglyceride metabolism in hyper...

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Bibliographic Details
Main Authors: Jiaqi Li, Mingchao Wang, Kai Qu, Yuyao Sun, Zequn Yin, Na Dong, Xin Sun, Yitong Xu, Liang Chen, Shuang Zhang, Xunde Xian, Suowen Xu, Likun Ma, Yajun Duan, Haibo Zhu
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
IMM-H007
AMPK
Cholesterol
LDLR
FXR
Hypercholesterolemia
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525003193
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