Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations
BackgroundBrain arteriovenous malformations (AVMs) are congenital vascular anomalies that can affect cognitive, particularly memory functions. However, the underlying mechanisms of neurocognitive abnormalities in unruptured AVMs remain unclear. This study aimed to explore spontaneous functional netw...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2025.1568045/full |
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| author | Anqi Li Xiaofeng Deng Kexin Yuan Yu Chen Zhipeng Li Xiaolin Chen Yuanli Zhao |
| author_facet | Anqi Li Xiaofeng Deng Kexin Yuan Yu Chen Zhipeng Li Xiaolin Chen Yuanli Zhao |
| author_sort | Anqi Li |
| collection | DOAJ |
| description | BackgroundBrain arteriovenous malformations (AVMs) are congenital vascular anomalies that can affect cognitive, particularly memory functions. However, the underlying mechanisms of neurocognitive abnormalities in unruptured AVMs remain unclear. This study aimed to explore spontaneous functional network reorganization associated with memory impairment in unruptured AVM patients using resting-state functional MRI (rsfMRI).MethodsUsing rsfMRI data, we compared functional activity and connectivity patterns between 25 AVM patients and healthy controls, including regional homogeneity (ReHo), fractional amplitude of low-frequency fluctuations (fALFF), seed-based functional connectivity (FC), and lesion network mapping. Correlation analysis was performed to clarify the relationship between these parameters and memory performance in AVM patients.ResultsWe identified memory-related spontaneous functional network reorganization in AVM patients, particularly involving the somatomotor network (SMN), frontoparietal control network (FPN), and default mode network (DMN). Subgroup analyses based on lesion location (frontal vs. non-frontal) and laterality (left vs. right) revealed location-dependent differences in connectivity reorganization. In particular, left-sided AVMs showed disrupted FC within the SMN, correlated with working memory and executive function, while right-sided and frontal AVMs exhibited more complex patterns involving multiple networks. Moreover, functional disconnection maps indicated that AVM lesions did not directly impair resting-state memory networks.ConclusionPatients with unruptured AVMs exhibit resting-state memory network reorganization, which is closely related to the lesion location. These findings highlight the functional network alterations in AVM patients and suggest the potential neural mechanisms underlying memory deficits. |
| format | Article |
| id | doaj-art-2e032c0ec35b4893a24c5e65d67b7d57 |
| institution | DOAJ |
| issn | 1662-453X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj-art-2e032c0ec35b4893a24c5e65d67b7d572025-08-20T03:06:13ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2025-04-011910.3389/fnins.2025.15680451568045Functional network reorganization and memory impairment in unruptured brain arteriovenous malformationsAnqi Li0Xiaofeng Deng1Kexin Yuan2Yu Chen3Zhipeng Li4Xiaolin Chen5Yuanli Zhao6Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, ChinaDepartment of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaBackgroundBrain arteriovenous malformations (AVMs) are congenital vascular anomalies that can affect cognitive, particularly memory functions. However, the underlying mechanisms of neurocognitive abnormalities in unruptured AVMs remain unclear. This study aimed to explore spontaneous functional network reorganization associated with memory impairment in unruptured AVM patients using resting-state functional MRI (rsfMRI).MethodsUsing rsfMRI data, we compared functional activity and connectivity patterns between 25 AVM patients and healthy controls, including regional homogeneity (ReHo), fractional amplitude of low-frequency fluctuations (fALFF), seed-based functional connectivity (FC), and lesion network mapping. Correlation analysis was performed to clarify the relationship between these parameters and memory performance in AVM patients.ResultsWe identified memory-related spontaneous functional network reorganization in AVM patients, particularly involving the somatomotor network (SMN), frontoparietal control network (FPN), and default mode network (DMN). Subgroup analyses based on lesion location (frontal vs. non-frontal) and laterality (left vs. right) revealed location-dependent differences in connectivity reorganization. In particular, left-sided AVMs showed disrupted FC within the SMN, correlated with working memory and executive function, while right-sided and frontal AVMs exhibited more complex patterns involving multiple networks. Moreover, functional disconnection maps indicated that AVM lesions did not directly impair resting-state memory networks.ConclusionPatients with unruptured AVMs exhibit resting-state memory network reorganization, which is closely related to the lesion location. These findings highlight the functional network alterations in AVM patients and suggest the potential neural mechanisms underlying memory deficits.https://www.frontiersin.org/articles/10.3389/fnins.2025.1568045/fullworking memoryunruptured arteriovenous malformationneurocognitionresting-state functional magnetic resonance imagingfunctional connectivity |
| spellingShingle | Anqi Li Xiaofeng Deng Kexin Yuan Yu Chen Zhipeng Li Xiaolin Chen Yuanli Zhao Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations Frontiers in Neuroscience working memory unruptured arteriovenous malformation neurocognition resting-state functional magnetic resonance imaging functional connectivity |
| title | Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| title_full | Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| title_fullStr | Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| title_full_unstemmed | Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| title_short | Functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| title_sort | functional network reorganization and memory impairment in unruptured brain arteriovenous malformations |
| topic | working memory unruptured arteriovenous malformation neurocognition resting-state functional magnetic resonance imaging functional connectivity |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2025.1568045/full |
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