Comparative genomic analysis of trypanosomatid protists illuminates an extensive change in the nuclear genetic code

Comparative genomic analysis of trypanosomatid protists illuminates an extensive change in the nuclear genetic code

ABSTRACT Trypanosomatids are among the most extensively studied protists due to their parasitic interactions with insects, vertebrates, and plants. Recently, Blastocrithidia nonstop was found to depart from the canonical genetic code, with all three stop codons reassigned to encode amino acids (UAR...

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Main Authors: Kristína Záhonová, Zoltán Füssy, Amanda T. S. Albanaz, Anzhelika Butenko, Ambar Kachale, Natalya Kraeva, Arnau Galan, Alexandra Zakharova, Bojana Stojanova, Jan Votýpka, Alexei Y. Kostygov, Viktoria V. Spodareva, Marina N. Malysheva, Alexander O. Frolov, Igor B. Rogozin, Zdeněk Paris, Leoš Shivaya Valášek, Vyacheslav Yurchenko, Julius Lukeš
Format: Article
Language:English
Published: American Society for Microbiology 2025-06-01
Series:mBio
Subjects:
AT-rich genomes
nuclear genetic code
reassigned codon
tRNA structure
eukaryotic release factors
termination of translation
Online Access:https://journals.asm.org/doi/10.1128/mbio.00885-25
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https://journals.asm.org/doi/10.1128/mbio.00885-25

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